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P, p'-DDE-13C12

P, p'-DDE-13C12 is 13C labeled p, p'-DDE. p, p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1][2].

Product Specifications

CAS Number

201612-50-2

Product Name Alternative

4,4'-DDE-13C12; p, p'-Dichlorodiphenyldichloroethylene-13C12

UNSPSC

12352005

Target

Androgen Receptor; Drug Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/p-p-dde-13c12.html

Smiles

C(=C(Cl)Cl)([13C]1=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]1)[13C]2=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]2

Molecular Formula

C2 13C12H8Cl4

Molecular Weight

329.94

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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