SIRT1-IN-3
SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1].
Product Specifications
CAS Number
[2470969-91-4]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt1-in-3.html
Concentration
10mM
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=C(NC2=CC=C(C=C21)Br)CC(N)=O)C
Molecular Formula
C13H15BrN2O
Molecular Weight
295.18
References & Citations
[1]Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2
Available Sizes
Curated Selection
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