What is the catalog number for DM3?

The catalog number for DM3 is HY-130080.

What sizes are available for DM3?

DM3 is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg.

How many pack sizes does DM3 come in?

DM3 is available in 4 different pack sizes.

DM3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DM3?

DM3 is manufactured by QuantiMol.

What is the estimated delivery time for DM3?

Estimated delivery time for DM3 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DM3?

The safety data sheet for DM3 is available here: http://file.medchemexpress.com/batch_PDF/HY-130080/DM3-SDS-MedChemExpress.pdf.

DM3

DM3 (Maytansinoid DM3), a Maytansine analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs)[2].

Product Specifications

CAS Number

796073-54-6

Product Name Alternative

Maytansinoid DM3

UNSPSC

12352203

Target

ADC Payload; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dm3.html

Concentration

10mM

Purity

95.59

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

Molecular Formula

C37H52ClN3O10S

Molecular Weight

766.34

References & Citations

[1]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22 (8) .|[2]Griffin P, et al. High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model. Cancer Cell Int. 2023 Apr 5;23 (1) :60.