Desmethyl cariprazine

Desmethyl cariprazine is an active metabolite of Cariprazine[1]. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM) [2].

Product Specifications

CAS Number

[839712-15-1]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desmethyl-cariprazine.html

Purity

98.08

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(NC)N[C@@H]1CC[C@@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1

Molecular Formula

C20H30Cl2N4O

Molecular Weight

413.38

References & Citations

[1]Campbell RH, et al. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7 (5) :221-229.|[2]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl) . 2011 Dec;218 (3) :579-8.