Senkyunolide I
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].
Product Specifications
CAS Number
94596-28-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Caspase
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/senkyunolide-i.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1O/C(C2=C1[C@H](O)[C@@H](O)CC2)=C\CCC
Molecular Formula
C12H16O4
Molecular Weight
224.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63 (2) :261-6.|[2]Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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