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[D-Phe2,6, Pro3]-LH-RH

[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist[1].

Product Specifications

CAS Number

[64789-67-9]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/d-phe2-6-pro3-lh-rh.html

Solubility

H2O

Smiles

O=C(N[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6)NC6=O

Molecular Formula

C59H80N14O13

Molecular Weight

1193.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wilks JW, et al. Effect of [D-Phe2, Pro3, D-Phe6]-luteinizing hormone releasing hormone, an antagonist, on preovulatory gonadotropin secretion in the rhesus monkey. Biol Reprod. 1980 Aug;23 (1) :1-9.|[2]Loumaye E, et al. Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells. Science. 1982 Feb 19;215 (4535) :983-5. |[3]Gian, et al. TRH, LHRH and Synthetic [D-Phe2-6, Pro3]-LHRH Stimulate in Vitro Thyrotropin Secretion by Crested Newt Pituitaries. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY: FROM MOLECULAR TO INTEGRATIVE BIOLOGY. 1998;839 (1) :522-523.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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