CRT0066854

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

Product Specifications

CAS Number

[1438881-19-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

PKC; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crt0066854.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5

Molecular Formula

C24H25N5S

Molecular Weight

415.55

Precautions

H315, H319, H320

References & Citations

[1]Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451 (2) :329-42.