Flupentixol (dihydrochloride)
Product Specifications
UNSPSC Description
Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].
Target Antigen
Apoptosis; Dopamine Receptor; PI3K
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Flupentixol_dihydrochloride.html
Solubility
DMSO : 33.33 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
Molecular Weight
507.44
References & Citations
[1]Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.|[2]Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.|[3]Chao Dong, et al. The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. Int J Biol Sci. 2019 Jun 2;15(7):1523-1532.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15856B/Flupentixol-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15856B/Flupentixol-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
2413-38-9
Available Sizes
Curated Selection
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