NLRP3-IN-25
NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].
Product Specifications
CAS Number
2660230-90-8
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-25.html
Purity
99.78
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(C1=COC(NC2=CC(C(F)(F)F)=CC=C2C)=N1)NS(=O)(N3CCOCCC3)=O
Molecular Formula
C17H19F3N4O5S
Molecular Weight
448.42
References & Citations
[1]Ohba Y et al. Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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