Desvenlafaxine

Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

Product Specifications

CAS Number

[93413-62-8]

Product Name Alternative

O-Desmethylvenlafaxine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desvenlafaxine.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1

Molecular Formula

C16H25NO2

Molecular Weight

263.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318 (2) : p. 657-65.|[2]Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42 (10) : p. 1439-46.