Recombinant Human SNCα Protein (Trx Tag)
Product Specifications
Background
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB) .
Abbreviation
SNCα
Synonyms
Fetal liver kinase; Protein-tyrosine kinase receptor flk; Vascular endothelial growth factor receptor; PD1; NACP; PARK1; PARK4; SNCA; SNC-A; aSYN; CD309; Fetal liver kinase 1; FLK1; FLK-1; KDR; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR2; VEGFR-2; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; alpha (non A4 component of amyloid precursor) ; Alpha synuclein; alphaSYN; isoform NACP140; Lewy body) 4; MGC105443; MGC110988; MGC127560; MGC64356; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A4 component of amyloid; Non-A-beta component of alzheimers disease amyloid; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; Parkinson disease (autosomal dominant; Parkinson disease familial 1; precursor of; Snca synuclein; SYN; Synuclein; Synuclein alpha; Synuclein alpha 140; SYUA
UniProt
P37840
Accession Number
P37840
Expression System
E.coli
Tag
N-Trx
Sequence
Met1-Ala140
Field of Research
Neuroscience; Signal Transduction; Cancer
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
35.2 kDa
Observed Molecular Weight
37 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Curated Selection
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