Tacrine (hydrochloride)

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

Product Specifications

CAS Number

[1684-40-8]

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335, H351

Target

Cholinesterase (ChE) ; iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tacrine-hydrochloride.html

Concentration

10mM

Purity

99.90

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl

Molecular Formula

C13H15ClN2

Molecular Weight

234.73

Precautions

H301+H311+H331, H315, H319, H335, H351

References & Citations

[1]Ahmed M, et, al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25; 162 (2) :165-71.c|[2]Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62.|[3]The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8 (5) : 884-90.