F5446
F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo[1][2][3].
Product Specifications
CAS Number
2304465-89-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/f5446.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=C(C3=O)NC=C2C(OCC4=CC=CC=C4)=O)=C(N1S(=O)(C5=CC=C(C=C5)Cl)=O)C3=O)OC
Molecular Formula
C26H17ClN2O8S
Molecular Weight
552.94
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Complement C4d (C4D204), CF488A conjugate, 0.1mg/mL
Cytokeratin, HMW (AE-3), CF568 conjugate, 0.1mg/mL
Histone H1 (AE-4), CF488A conjugate, 0.1mg/mL
BARX1 (Prognostic Biomarker in Hepatocellular Carcinoma) (BARX1/2759), CF568 conjugate, 0.1mg/mL
MyoD1 (5.8A + MYD712), CF647 conjugate, 0.1mg/mL
