Poly-L-lysine (hydrobromide) (MW 30000-70000)

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[25988-63-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; MDM-2/p53; VEGFR

Type

Oligonucleotides

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/poly-l-lysine-hydrobromide.html

Purity

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CN[C@@H](CCCC[NH3+])C(C)=O.[n].[Br-].[n]

Molecular Formula

(C6H14N2O2) n.nBrH

Molecular Weight

30000-70000

Precautions

H302, H315, H319, H335

References & Citations

[1]Archishman Ghosh, et al. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019;116 (39) :19474-19483. |[2]Debnath S, et al. Poly-L-Lysine Inhibits Tumor Angiogenesis and Induces Apoptosis in Ehrlich Ascites Carcinoma and in Sarcoma S-180 Tumor. Asian Pac J Cancer Prev. 2017 Aug 27;18 (8) :2255-2268.|[3]Mukherjee A, et al. DNA interactive property of poly-L-lysine induces apoptosis in MCF-7 cells through DNA interaction. J Biochem Mol Toxicol. 2023 Aug;37 (8) :e23378. |[4]Debnath S, et al. Induction of apoptosis, anti-proliferation, tumor-angiogenic suppression and down-regulation of Dalton's Ascitic Lymphoma (DAL) induced tumorigenesis by poly-l-lysine: A mechanistic study. Biomed Pharmacother. 2018 Jun;102:1064-1076.|[5]Shier WT, et al. Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly (L-lysine) and other synthetic polycations. Biochim Biophys Acta. 1984 Apr 18;793 (2) :238-50.|[6]Barrantes A, et al. Poly-l-lysine/heparin multilayer coatings prevent blood protein adsorption. J Colloid Interface Sci. 2017 Jan 1;485:288-295.|[7]Debnath S, et al. Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model. Int J Biol Macromol. 2021 Jul 31;183:528-548.|[8]Lin CW, et al. Protective role of autophagy in branched polyethylenimine (25K) - and poly (L-lysine) (30-70K) -induced cell death. Eur J Pharm Sci. 2012 Dec 18;47 (5) :865-74.