SMARCA-BD ligand 1 for PROTAC (hydrochloride)
SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].
Product Specifications
CAS Number
[2380272-56-8]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SWI/SNF Complex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca-bd-ligand-1-for-protac-hydrochloride.html
Purity
99.24
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl
Molecular Formula
C14H18ClN5O
Molecular Weight
307.78
References & Citations
[1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15 (7) :672-680.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Protein Polybromo-1; SMARCA2; SMARCA4
Available Sizes
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