C-176
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].
Product Specifications
CAS Number
314054-00-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/C-176.html
Purity
99.45
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2
Molecular Formula
C11H7IN2O4
Molecular Weight
358.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.|[2]Zhang LM, et al. STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury. J Neurochem. 2022 Sep;162 (5) :444-462.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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