C-176

C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].

Product Specifications

CAS Number

[314054-00-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/C-176.html

Purity

99.45

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2

Molecular Formula

C11H7IN2O4

Molecular Weight

358.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.|[2]Zhang LM, et al. STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury. J Neurochem. 2022 Sep;162 (5) :444-462.