N-Hydroxyphthalimide

N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473) . N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].

Product Specifications

CAS Number

[524-38-9]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Survivin

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-hydroxyphthalimide.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C(N1O)=O)C=CC=C2

Molecular Formula

C8H5NO3

Molecular Weight

163.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei W J, et al. Study on N‐hydroxyphthalimide as blocking agent for isocyanates. Journal of applied polymer science, 2002, 84 (7) : 1346-1352. |[2]Melone L, et al. N-Hydroxyphthalimide catalysts as bioactive pro-oxidants. RSC Advances, 2016, 6 (26) : 21749-21755. |[3]Wang M, et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. J Exp Clin Cancer Res. 2016 Mar 3;35:41.