Inolitazone (dihydrochloride)
Product Specifications
UNSPSC Description
Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition.
Target Antigen
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/inolitazone-dihydrochloride.html
Solubility
DMSO : 2 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : < 0.1 mg/mL
Smiles
O=C(N1)SC(CC2=CC=C(OCC3=NC4=CC=C(OC5=CC(C)=C(N)C(C)=C5)C=C4N3C)C=C2)C1=O.Cl.Cl
Molecular Weight
575.51
References & Citations
[1]Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17.|[2]Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44.Cancer Med. 2018 May;7(5):1955-1966. |Int J Oncol. 2018 Jun;52(6):1991-2000. |Exp Cell Res. 2017 Dec 15;361(2):246-256. |Front Microbiol. 2019 Jan 8;9:3257.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14792B/Inolitazone-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14792B/Inolitazone-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
223132-38-5
Available Sizes
Curated Selection
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