Pan-KRAS-IN-2
Pan-KRAS-IN-2 (Compound 6) is a pan-inhibitor with IC50s ≤ 10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A and Q61H) ; and an IC50 > 10 μM for KRAS G13D. pan-KRAS-IN-2 can be used to study various KRAS-mediated cancers, such as pancreatic cancer and colorectal cancer[1].
Product Specifications
CAS Number
2882825-14-9
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-2.html
Purity
98.01
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)C=CC4=C1N=C(N=C4N5CCCOCC5)OC[C@@]67N(CCC7)C[C@@H](C6)F
Molecular Formula
C34H34F2N4O3
Molecular Weight
584.66
References & Citations
[1]Jones C, et al. Quinazoline derivatives useful as Ras inhibitors and their preparation. World Intellectual Property Organization, WO2022258974 A1. 2022-12-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Frequently Asked Questions
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