Imifoplatin

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity[1][2][3].

Product Specifications

CAS Number

[1339960-28-9]

Product Name Alternative

PT-112

UNSPSC

12352005

Target

Apoptosis; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/imifoplatin.html

Purity

95.0

Solubility

H2O : 1.25 mg/mL (ultrasonic)

Smiles

O=[P]([O-][Pt+2]1([O-][P]2(O)=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]1)(O2)O

Molecular Formula

C6H16N2O7P2Pt

Molecular Weight

485.23

References & Citations

[1]Moghaddas S, et, al. Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets. Inorganica Chimica Acta. 2012 Dec; 393 (1) : 173-181.|[2]Yamazaki T, et al. PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models. Oncoimmunology. 2020 Feb 11;9 (1) :1721810.|[3]Soler-Agesta R, et al. PT-112 induces mitochondrial stress and immunogenic cell death, targeting tumor cells with mitochondrial deficiencies[J]. Cancers, 2022, 14 (16) : 3851.