Emixustat
Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) [1][2][3][4].
Product Specifications
CAS Number
1141777-14-1
Product Name Alternative
ACU-4429
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
RPE65
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Emixustat.html
Purity
98.74
Solubility
DMSO : ≥ 43 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
Smiles
O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1
Molecular Formula
C16H25NO2
Molecular Weight
263.38
Precautions
H302, H315, H319
References & Citations
[1]Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10 (5) :e0124940.|[2]Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11 (6) :409-15.|[3]Kubota R, et al. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 1;60 (14) :4924-4930.|[4]Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10 (5) :e0124940.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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