Luteolin 7-O-glucuronide

Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively[1].

Product Specifications

CAS Number

[29741-10-4]

Product Name Alternative

Luteolin 7-glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MMP

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Luteolin_7-O-glucuronide.html

Purity

99.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C(O)=C4)OC3=C2)=O

Molecular Formula

C21H18O12

Molecular Weight

462.36

Precautions

H302, H315, H319

References & Citations

[1]Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83 (11) :901-911.|[2]Cho YC, et al. Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation. Int J Mol Sci. 2020 Mar 16;21 (6) :2007. |[3]Ryu D, et al. Luteolin-7-O-Glucuronide Improves Depression-like and Stress Coping Behaviors in Sleep Deprivation Stress Model by Activation of the BDNF Signaling. Nutrients. 2022 Aug 12;14 (16) :3314.