6-O-Methyl Guanosine

6-O-Methyl Guanosine is a modified nucleoside[1]. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line[2].

Product Specifications

CAS Number

[7803-88-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-O-Methyl_Guanosine.html

Purity

99.65

Solubility

DMSO : 130 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C=N2)C3=C2C(OC)=NC(N)=N3)O1

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21 (19) :4444-50.|[2]Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1- (2-chloroethyl) -1-nitroso-3- (2-hydroxyethyl) -urea. J Cancer Res Clin Oncol. 1987;113 (1) :67-72.