N6-Methyladenosine-d3

N6-Methyladenosine-d3 (6-Methyladenosine-d3; N-Methyladenosine-d3) is a deuterium labeled N6-Methyladenosine (HY-N0086) . N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

Product Specifications

CAS Number

[139896-43-8]

Product Name Alternative

6-Methyladenosine-d3; N-Methyladenosine-d3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Influenza Virus; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.97

Solubility

DMSO : 31 mg/mL (ultrasonic; warming)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN=C3NC([2H])([2H])[2H])=C3N=C2)O1

Molecular Formula

C11H12D3N5O4

Molecular Weight

284.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505 (7481) :117-20.|[3]Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21 (8) :1511-8.|[4]Dang W, et al. N6-Methyladenosine and Viral Infection. Front Microbiol. 2019 Mar 5;10:417.