3-O-Methyldopa

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB) . 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease[1][2].

Product Specifications

CAS Number

[300-48-1]

Product Name Alternative

3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative; Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-o-methyldopa.html

Purity

99.90

Solubility

H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@@H](CC1=CC=C(O)C(OC)=C1)C(O)=O

Molecular Formula

C10H13NO4

Molecular Weight

211.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17 (1) :52.|[2]Zhong Q, et al. Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression. Ann Med. 2024 Dec;56 (1) :2417179.