CM037

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM) . CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].

Product Specifications

CAS Number

[896795-60-1]

Product Name Alternative

A37

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cm037.html

Purity

99.55

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N=C(SCC(OCC)=O)N1CCCN3CCCC3)C4=CC=CC=C4S2

Molecular Formula

C21H25N3O3S2

Molecular Weight

431.57

Precautions

H302, H315, H319

References & Citations

[Content Brief]

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALDH1

Available Sizes

Curated Selection

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