CM037
CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM) . CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].
Product Specifications
CAS Number
896795-60-1
Product Name Alternative
A37
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cm037.html
Purity
99.55
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(N=C(SCC(OCC)=O)N1CCCN3CCCC3)C4=CC=CC=C4S2
Molecular Formula
C21H25N3O3S2
Molecular Weight
431.57
Precautions
H302, H315, H319
References & Citations
[Content Brief]
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Exiguobacterium sp. DNA replication and repair protein recF (recF)
Recombinant Exiguobacterium sp. DNA replication and repair protein recF (recF)
Recombinant Exiguobacterium sp. DNA replication and repair protein recF (recF)
Recombinant Exiguobacterium sp. DNA replication and repair protein recF (recF)
Recombinant Exiguobacterium sp. DNA replication and repair protein recF (recF)