TAK-593

TAK-593 is a potent VEGFR and PDGFR family inhibitor with IC50s of 3.2, 0.95, 1.1, 4.3 and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα and PDFGRβ, respectively.

Product Specifications

CAS Number

[1005780-62-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TAK-593.html

Purity

99.66

Solubility

DMSO : ≥ 48.5 mg/mL

Smiles

O=C(C1=CC(C)=NN1C)NC2=CC(OC3=NN4C(C=C3)=NC(NC(C5CC5)=O)=C4)=CC=C2C

Molecular Formula

C23H23N7O3

Molecular Weight

445.47

Precautions

H302, H315, H319

References & Citations

[1]Miyamoto N, et al. Discovery of N-[5- ({2-[ (cyclopropylcarbonyl) amino]imidazo[1,2-b]pyridazin-6-yl}oxy) -2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor. Bioorg Med Chem. 2013 Apr 15;21 (8) :2333-2345.|[2]Awazu Y, et al. Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase. Cancer Sci. 2013 Apr;104 (4) :486-94.