Fisetin

Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

Product Specifications

CAS Number

[528-48-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR; Sirtuin; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Fisetin.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC=C13

Molecular Formula

C15H10O6

Molecular Weight

286.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467 (4) :638-44.|[2]Mukhtar E, et al. Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells. Cancer Lett. 2015 Oct 28;367 (2) :173-83.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

Phase 4

Citation 01

Acta Pharmacol Sin. 2023 Oct;44 (10) :2065-2074.|Aging (Albany NY) . 2021 Nov 25;13 (22) :24753-24767.|Autophagy. 2025 Jul 27:1-23.|Biochem Biophys Res Commun. 2018 Sep 3;503 (1) :297-303.|Biochem Pharmacol. 2025 Apr 3:116919.|Biochim Biophys Acta Mol Basis Dis. 2024 Sep 13:167515.|Biol Direct. 2025 Apr 2;20 (1) :43.|Biomolecules. 2025 Jun 16;15 (6) :873.|bioRxiv. 2024 Jul 30:2024.07.29.605645.|Cell Stem Cell. 2025 Dec 4;32 (12) :1869-1885.e8.|Cells. 2022 Jun 21;11 (13) :1992.|Eur J Nutr. 2025 Mar 19;64 (3) :128.|Eur J Pharmacol. 2024 Feb 5:964:176298.|Fish Shellfish Immunol. 2025 Aug 6:166:110633.|Food Sci Nutr. 2025 Sep 3;13 (9) :e70892.|Hepatob Pancreat Dis. 2021 Aug;20 (4) :352-360.|Int J Mol Sci. 2025 May 22;26 (11) :4978.|J Ethnopharmacol. 2024 Jun 14:118421.|J Mol Liq. 23 November 2021, 118164.|J Nutr Biochem. 2023 Dec:122:109452.|JCI Insight. 2025 Jan 23;10 (2) :e180248.|Journal of Harran University Medical Faculty. 2023 Sep 6.|Microbiol Spectr. 2025 Aug 21:e0152725.|Mol Cancer Ther. 2025 Jul 2.|Molecules. 2023 Jul 20;28 (14) :5533.|Nat Aging. 2024 Apr;4 (4) :527-545.|Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398 (2) :1665-1679.|PeerJ. 2025 Mar 28:13:e19198.|Research Square Preprint. 2023 Nov 20.|Int J Mol Sci. 2024 Mar 27;25 (7) :3724.