Pregnenolone 16α-carbonitrile

Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults[1][2][3].

Product Specifications

CAS Number

[1434-54-4]

UNSPSC

12352211

Target

Cytochrome P450; Pregnane X Receptor (PXR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pregnenolone-16α-carbonitrile.html

Purity

98.48

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C[C@H]([C@@H]2C(C)=O)C#N)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@H](CC4)O)=CC3)C)([H])CC1

Molecular Formula

C22H31NO2

Molecular Weight

341.49

References & Citations

[1]Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70 (3) :995-1010.|[2]Simon Lowes, et al. The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2 (1) :61-77.|[3]Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94 (2) :379-87.|[4]Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor) -dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387 (Pt 3) :601-8.