(S) -AM-9022

(S) -AM-9022 is the S-enantiomer of AM-9022 (HY-162110) . AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer[1].

Product Specifications

CAS Number

[2446872-47-3]

UNSPSC

12352005

Target

Drug Isomer; Kinesin; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-am-9022.html

Purity

99.88

Smiles

O=C(C1=CC=C(NS([C@@H](C)CO)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC(C)=NC(N5CCC(F)(F)CC5)=N4

Molecular Formula

C27H36F2N6O4S

Molecular Weight

578.67

References & Citations

[1]Payton M, et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2023 Dec 27.