JTP10-△-R9 (TFA)

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC50 of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3[1].

Product Specifications

UNSPSC

12352209

Target

JNK

Type

Peptides

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jtp10-r9-tfa.html

Purity

99.41

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(CCCCCNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC([C@H]2N(CCC2)C(C)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(N)=O)=O)CC(C)C)=O)CC3=CC=CC=C3)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N.OC(C(F)(F)F)=O

Molecular Formula

C119H214F3N53O26

Molecular Weight

2860.31

References & Citations

[1]Tamer S. Kao, et al. Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration. ACS Chem Biol. 2011 Jun 17;6 (6) :658-66.