M443
M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM.
Product Specifications
CAS Number
1820684-31-8
UNSPSC
12352005
Target
Mixed Lineage Kinase
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/M443.html
Purity
99.92
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(NC(C2=CC(NC3=NC=CC(C4CN(C(C=C)=O)CCC4)=N3)=C(C)C=C2)=O)=CC(N5C=NC(C)=C5)=C1
Molecular Formula
C31H30F3N7O2
Molecular Weight
589.61
References & Citations
[1]Markowitz D, et al. Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma. Mol Cancer Ther. 2016 Aug;15 (8) :1799-808.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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