M443
M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM.
Product Specifications
CAS Number
1820684-31-8
UNSPSC
12352005
Target
Mixed Lineage Kinase
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/M443.html
Purity
99.92
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(NC(C2=CC(NC3=NC=CC(C4CN(C(C=C)=O)CCC4)=N3)=C(C)C=C2)=O)=CC(N5C=NC(C)=C5)=C1
Molecular Formula
C31H30F3N7O2
Molecular Weight
589.61
References & Citations
[1]Markowitz D, et al. Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma. Mol Cancer Ther. 2016 Aug;15 (8) :1799-808.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
ARP33400_P050-Biotin 100 µL
TBX2 Antibody - middle region : Biotin (ARP33400_P050-Biotin)
Sign In for Pricing
View Details 
K0454107 1.0 µg DNA
CIRH1A sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details K4291707 1.0 µg DNA
Olfr659 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details 