(S) - (+) -Carvone

(S) - (+) -Carvone is an orally active natural product. (S) - (+) -Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S) - (+) -Carvone increases the activities of caspase-8, -9 and -3. (S) - (+) -Carvone induces apoptotic death. (S) - (+) -Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S) - (+) -Carvone improves memory and arthritis[1][2][3][4][5][6][7][8][9][10][11][12].

Product Specifications

CAS Number

[2244-16-8]

Product Name Alternative

D-Carvone

UNSPSC

12352211

Hazard Statement

H227, H315, H319, H335

Target

Apoptosis; Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; SOD

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-carvone.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=C([C@H](C1)CC=C(C)C1=O)C

Molecular Formula

C10H14O

Molecular Weight

150.22

Precautions

H227, H315, H319, H335

References & Citations

[1]Jan Alexander, et al. Scientific Opinion on the safety assessment of carvone, considering all sources of exposure.European Food Safety Authority (EFSA), Parma, Italy.|[2]Lv L, et al. d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells. J Biochem Mol Toxicol. 2021 May;35 (5) :e22746. |[3]Wojtunik-Kulesza KA, et al. S- (+) -Carvone, a Monoterpene with Potential Anti-Neurodegenerative Activity-In Vitro, In Vivo and Ex Vivo Studies. Molecules. 2024 Sep 13;29 (18) :4365.|[4]Iyappan P, et al. D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4) . Bioinformation. 2021 Jan 31;17 (1) :171-180. |[5]Sousa C, et al. Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S) - (+) -Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line. Biomedicines. 2021 Jul 4;9 (7) :777.|[6]Huchelmann A, et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol. 2014 Feb;164 (2) :935-50. |[7]Zhao M, et al. Anti-inflammatory and protective effects of D-carvone on lipopolysaccharide (LPS) -induced acute lung injury in mice. Journal of King Saud University-Science, 2020, 32 (2) : 1592-1596.|[8]Dai M, et al. D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway. Biomed Pharmacother. 2020 Dec;132:110870.|[9]Chen G, et al. Anti-arthritic activity of D-carvone against complete Freund's adjuvant-induced arthritis in rats through modulation of inflammatory cytokines. Korean J Physiol Pharmacol. 2020 Nov 1;24 (6) :453-462.|[10]Nogoceke FP, et al. Antimanic-like effects of (R) - (-) -carvone and (S) - (+) -carvone in mice. Neurosci Lett. 2016 Apr 21;619:43-8.|[11]Alsanea S, et al. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharm Res. 2017 Nov;34 (11) :2241-2249.|[12]Gopalakrishnan T, et al. Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events. Biomed Pharmacother. 2019 Mar;111:178-187.