Oxeladin (citrate)

Oxeladin citrate is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM) . Oxeladin can be used for pulmonary diseases and stroke research[1][2].

Product Specifications

CAS Number

[52432-72-1]

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease; Others

Assay Protocol

https://www.medchemexpress.com/Oxeladin-citrate.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

Smiles

O=C(OCCOCCN(CC)CC)C(CC)(CC)C1=CC=CC=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O

Molecular Formula

C26H41NO10

Molecular Weight

527.60

Precautions

H301+H311+H331

References & Citations

[1]Schreihofer DA, et al. Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors. Transl Stroke Res. 2023. Epub ahead of print.|[2]Dalwadi DA, et al. Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands. J Pharmacol Toxicol Methods. 2022;113:107129.