Teprotumumab
Product Specifications
UNSPSC Description
Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].
Target Antigen
IGF-1R; TSH Receptor
Type
Inhibitory Antibodies
Related Pathways
GPCR/G Protein;Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/teprotumumab.html
Purity
99.46
Solubility
10 mM in DMSO
Smiles
[Teprotumumab]
References & Citations
[1]Chen H, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014 Sep;99(9):E1635-40.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P99165/Teprotumumab-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P99165/Teprotumumab-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1036734-93-6
Available Sizes
Curated Selection
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