Pigment Epithelium-derived Factor (Human)

<strong>Pigment Epithelium-derived Factor (Human, Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010322_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Pigment Epithelium-derived Factor (Human, Recombinant) expressed in E. coli. This protein acts as a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuPEDF; SerpinF1; EPC-1_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Huang KT, Lin CC, Tsai MC, Chen KD, Chiu KW. Pigment epithelium-derived_x000D_ factor in lipid metabolic disorders. Biomed J. 2018 Apr;41(2):102-108._x000D_ _x000D_ 2: Brook N, Brook E, Dharmarajan A, Chan A, Dass CR. Pigment epithelium-derived_x000D_ factor regulation of neuronal and stem cell fate. Exp Cell Res. 2020 Apr_x000D_ 15;389(2):111891._x000D_ _x000D_ 3: Xi L. Pigment Epithelium-Derived Factor as a Possible Treatment Agent for_x000D_ Choroidal Neovascularization. Oxid Med Cell Longev. 2020 Mar 6;2020:8941057._x000D_ _x000D_ 4: Miller I, Bar-Joseph H, Nemerovsky L, Ben-Ami I, Shalgi R. Pigment_x000D_ epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features. J_x000D_ Endocrinol. 2020 May;245(2):291-300._x000D_ _x000D_ 5: Brook N, Brook E, Dharmarajan A, Chan A, Dass CR. The role of pigment_x000D_ epithelium-derived factor in protecting against cellular stress. Free Radic Res._x000D_ 2019 Dec;53(11-12):1166-1180._x000D_ _x000D_ 6: Yamagishi SI, Koga Y, Sotokawauchi A, Hashizume N, Fukahori S, Matsui T, Yagi_x000D_ M. Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer. Curr_x000D_ Pharm Des. 2019;25(3):313-324._x000D_ _x000D_ 7: Yamagishi SI, Matsui T. Pigment Epithelium_Derived Factor: A Novel_x000D_ Therapeutic Target for Cardiometabolic Diseases and Related Complications. Curr_x000D_ Med Chem. 2018;25(13):1480-1500._x000D_ _x000D_ 8: Baxter-Holland M, Dass CR. Pigment epithelium_derived factor: a key mediator_x000D_ in bone homeostasis and potential for bone regenerative therapy. J Pharm_x000D_ Pharmacol. 2018 Sep;70(9):1127-1138._x000D_ _x000D_ 9: Huang WT, Chong IW, Chen HL, Li CY, Hsieh CC, Kuo HF, Chang CY, Chen YH, Liu_x000D_ YP, Lu CY, Liu YR, Liu PL. Pigment epithelium_derived factor inhibits lung_x000D_ cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer_x000D_ Lett. 2019 Feb 1;442:287-298._x000D_ _x000D_ 10: Ma S, Wang S, Li M, Zhang Y, Zhu P. The effects of pigment epithelium-_x000D_ derived factor on atherosclerosis: putative mechanisms of the process. Lipids_x000D_ Health Dis. 2018 Oct 17;17(1):240._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30726852/">11: Akpinar MY, Kahramanoglu Aksoy E, Pirincci Sapmaz F, Ceylan Dogan O, Uzman_x000D_ M, Nazligul Y. Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac_x000D_ Disease. Med Princ Pract. 2019;28(3):236-241. </a>_x000D_ _x000D_ <strong>Products Related to Pigment Epithelium-derived Factor (Human, Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>