C1s Enzyme
Product Specifications
UNSPSC Description
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity[1].
Target Antigen
Wnt
Type
Enzyme
Related Pathways
Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/c1s-enzyme.html
Smiles
[C1s Enzyme]
References & Citations
[1]Yuan D, et al. Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway. Mol Immunol. 2024 Feb;166:29-38.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-E70390/C1s-Enzyme-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-E70390/
Clinical Information
No Development Reported
Curated Selection
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