C1s Enzyme

C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity[1].

Product Specifications

Product Name Alternative

Masp-2, c1 esterase, c1-esterase

UNSPSC

12352204

Target

Wnt

Type

Enzyme

Related Pathways

Stem Cell/Wnt

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/c1s-enzyme.html

Smiles

[C1sEnzyme]

References & Citations

[1]Yuan D, et al. Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway. Mol Immunol. 2024 Feb;166:29-38.