PROTAC CDK4/6 degrader 1
PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 ; Black: linker (HY-163788) ; Blue: ligand for E3 ligase (HY-10984) )
Product Specifications
CAS Number
3025082-14-5
UNSPSC
12352005
Target
Apoptosis; CDK; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-cdk4-6-degrader-1.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8
Molecular Formula
C41H47N11O6
Molecular Weight
789.88
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Available Sizes
Frequently Asked Questions
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