PROTAC CDK4/6 degrader 1

PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787) ; Black: linker (HY-163788) ; Blue: ligand for E3 ligase (HY-10984) ) [1]

Product Specifications

CAS Number

[3025082-14-5]

UNSPSC

12352005

Target

Apoptosis; CDK; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-cdk4-6-degrader-1.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8

Molecular Formula

C41H47N11O6

Molecular Weight

789.88

References & Citations

[1]He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67 (13) :11354-11364.