Sapurimycin
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA[1].
Product Specifications
CAS Number
[132609-35-9]
Product Name Alternative
Antibiotic DC 116
UNSPSC
12352005
Target
Antibiotic
Type
Natural Products
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sapurimycin.html
Smiles
O=C(O)CC(C=C1C(C2=C3C(O)=CC=C2O)=O)=C(C(C=C([C@@]4(C)O[C@H]4/C=C\C)O5)=O)C5=C1C3=O
Molecular Formula
C25H18O9
Molecular Weight
462.41
References & Citations
[1]PURIMYCIN, NEW ANTITUMOR ANTIBIOTIC PRODUCED BY STREPTOMYCES PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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