Naloxegol (oxalate)
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].
Product Specifications
CAS Number
1354744-91-4
Product Name Alternative
NKTR-118 (oxalate) ; AZ-13337019 (oxalate)
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Naloxegol-oxalate.html
Purity
99.91
Solubility
DMSO : ≥ 40 mg/mL
Smiles
O[C@@]1(CC[C@H](OCCOCCOCCOCCOCCOCCOCCOC)[C@]2([H])OC3=C4O)[C@]52C3=C(C=C4)C[C@@]1([H])N(CC=C)CC5.OC(C(O)=O)=O
Molecular Formula
C36H55NO15
Molecular Weight
741.82
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Eur J Pharmacol. 2021 Jul 15:903:174132.|Front Immunol. 2021 Jul 7:12:692286.
Available Sizes
Frequently Asked Questions
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