Aurora kinase inhibitor-2
Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].
Product Specifications
CAS Number
331770-21-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurora-kinase-inhibitor-2.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)C4=CC=CC=C4
Molecular Formula
C23H20N4O3
Molecular Weight
400.43
Precautions
H302, H315, H319
References & Citations
[1]Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5 (8) :807-21.|[2]Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16 (5) :1320-3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
Available Sizes
Frequently Asked Questions
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