Aurora kinase inhibitor-2

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].

Product Specifications

CAS Number

[331770-21-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aurora-kinase-inhibitor-2.html

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)C4=CC=CC=C4

Molecular Formula

C23H20N4O3

Molecular Weight

400.43

Precautions

H302, H315, H319

References & Citations

[1]Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5 (8) :807-21.|[2]Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16 (5) :1320-3.