Clemastine (fumarate)
Product Specifications
UNSPSC Description
Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
Target Antigen
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Clemastine-fumarate.html
Purity
99.97
Solubility
DMSO : 14.29 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Smiles
CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
Molecular Weight
459.96
References & Citations
[1]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.|[2]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cell Prolif. 2021 Jan;54(1):e12953.|Microbiol Spectr. 2022 Mar 2;e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2023 Nov 28:110901.|Viruses. 2021 Jun 28;13(7):1255.|Methods Mol Biol. 2023;2683:103-111.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0298A/Clemastine-fumarate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0298A/Clemastine-fumarate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
14976-57-9
Available Sizes
Curated Selection
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