Clemastine (fumarate)

Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[14976-57-9]

Product Name Alternative

HS-592 (fumarate) ; Meclastine (fumarate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Clemastine-fumarate.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 11.67 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)

Smiles

CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O

Molecular Formula

C25H30ClNO5

Molecular Weight

459.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42 (2) : p. 227-34.|[2]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD) : National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

H1 Receptor

Citation 01

Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Br J Pharmacol. 2025 Jun;182 (12) :2730-2753.|Cell Prolif. 2021 Jan;54 (1) :e12953.|Exp Neurol. 2024 Dec 3:115086.|Microbiol Spectr. 2022 Apr 27;10 (2) :e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8:129:110901.|Redox Biol. 2025 Sep 20:87:103875.|Viruses. 2021 Jun 28;13 (7) :1255.|Methods Mol Biol. 2023:2683:103-111.|Neurosci Bull. 2025 Jul 17.