PS-1145
PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
Product Specifications
CAS Number
431898-65-6
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; IKK
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PS-1145.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4
Molecular Formula
C17H11ClN4O
Molecular Weight
322.75
Precautions
H302
References & Citations
[1]Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277 (19) :16639-47.|[2]Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107 (2) :827-34.|[3]Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299 (1) :E47-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK
Available Sizes
Frequently Asked Questions
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