PS-1145

PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.

Product Specifications

CAS Number

[431898-65-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; IKK

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PS-1145.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4

Molecular Formula

C17H11ClN4O

Molecular Weight

322.75

Precautions

H302

References & Citations

[1]Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277 (19) :16639-47.|[2]Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107 (2) :827-34.|[3]Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299 (1) :E47-53.